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Issue:Comparison of different mathematical models of an E. coli fed-batch cultivation process using a generalized net model

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Title of paper: Comparison of different mathematical models of an E. coli fed-batch cultivation process using a generalized net model
Author(s):
Dimitar Dimitrov
Faculty of Mathematics and Informatics, Sofia University, 5 James Bourchier Str., Sofia, Bulgaria
Department of Bioinformatics and Mathematical Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 105 Acad G. Bonchev Str., 1113 Sofia, Bulgaria
dgdimitrov@fmi.uni-sofia.bg
Olympia Roeva
Department of Bioinformatics and Mathematical Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 105 Acad G. Bonchev Str., 1113 Sofia, Bulgaria
olympia@biomed.bas.bg
Presented at: 13th IWGN, London, 29 October 2012
Published in: Conference proceedings, pages 15—23
Download: Download-icon.png PDF (240  Kb, Info)
Abstract: In this paper, a generalized net model for comparison of different mathematical models of an E. coli fed-batch cultivation process is developed. The herewith proposed GN model is simulated using GN Lite – a software package for modeling and simulation with GNs. The GN model compares the set of mathematical models of a considered cultivation process and chooses, based on a predefined criterion, the best process model. During the simulation, the GN model calls the Matlab software environment to solve the process model, presented as a system of nonlinear differential equations. In the end of the simulation, the software package plots the main process variables’ dynamics with time.
Keywords: Generalized net, GN Lite, GNTicker, GN IDE, E. coli, Fed-batch cultivation, Mathematical models.
AMS Classification: 68Q85.
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